Innate DNA sensing moves to the nucleus

Unterholzner, Leonie and Bowie, Andrew G. (2011) Innate DNA sensing moves to the nucleus. Cell Host and Microbe, 9 (5). pp. 351-353. ISSN 1931-3128

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Abstract

It has been assumed that cells distinguish viral from cellular DNA due to the former's presence in the cytosol. However, in this issue, Kerur et al. (2011) propose that the DNA genome of Kaposi's sarcoma-associated herpesvirus (KSHV) is recognized inside the nucleus by the DNA sensor IFI16, leading inflammasome activation.

Item Type:
Journal Article
Journal or Publication Title:
Cell Host and Microbe
Additional Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2400
Subjects:
ID Code:
81770
Deposited By:
Deposited On:
23 Sep 2016 08:04
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Jan 2020 09:57