Extracting biomarkers of commitment to cancer development:potential role of vibrational spectroscopy in systems biology

Theophilou, Georgios and Paraskevaidi, Maria and Gomes De Lima, Kassio Michell and Kyrgiou, Maria and Martin-Hirsch, Pierre Leonard and Martin, Francis Luke (2015) Extracting biomarkers of commitment to cancer development:potential role of vibrational spectroscopy in systems biology. Expert Review of Molecular Diagnostics, 15 (5). pp. 693-713. ISSN 1473-7159

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Abstract

The complex processes driving cancer have so far impeded the discovery of dichotomous biomarkers associated with its initiation and progression. Reductionist approaches utilizing ‘omics’ technologies have met some success in identifying molecular alterations associated with carcinogenesis. Systems biology is an emerging science that combines high-throughput investigation techniques to define the dynamic interplay between regulatory biological systems in response to internal and external cues. Vibrational spectroscopy has the potential to play an integral role within systems biology research approaches. It is capable of examining global models of carcinogenesis by scrutinizing chemical bond alterations within molecules. The application of infrared or Raman spectroscopic approaches coupled with computational analysis under the systems biology umbrella can assist the transition of biomarker research from the molecular level to the system level. The comprehensive representation of carcinogenesis as a multilevel biological process will inevitably revolutionize cancer-related healthcare by personalizing risk prediction and prevention.

Item Type:
Journal Article
Journal or Publication Title:
Expert Review of Molecular Diagnostics
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2734
Subjects:
ID Code:
81179
Deposited By:
Deposited On:
24 Aug 2016 09:24
Refereed?:
Yes
Published?:
Published
Last Modified:
29 Jan 2020 03:24