Trial design for evaluating novel treatments during an outbreak of an infectious disease

Whitehead, John Raymond and Olliaro, Piero and Lang, Trudie and Horby, Peter W. (2016) Trial design for evaluating novel treatments during an outbreak of an infectious disease. Clinical Trials, 13 (1). pp. 31-38. ISSN 1740-7745

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Abstract

Tragically, the outbreak of Ebola that started in West Africa in 2014 has been far more extensive and damaging than any previous outbreaks. The duration of the outbreak has, for the first time, allowed the clinical evaluation of Ebola treatments. This article discusses the designs used for two such clinical trials which have recruited patients in Liberia and Sierra Leone. General principles are outlined for trial designs intended to be deployed quickly, adapt flexibly and provide results soon enough to influence the course of the current epidemic rather than just providing evidence for use should Ebola break out again. Lessons are drawn for the conduct of clinical research in future outbreaks of infectious diseases, where the sequence of events may or may not be similar to the West African Ebola epidemic.

Item Type:
Journal Article
Journal or Publication Title:
Clinical Trials
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700
Subjects:
ID Code:
81030
Deposited By:
Deposited On:
17 Aug 2016 14:54
Refereed?:
Yes
Published?:
Published
Last Modified:
24 Jun 2020 03:54