Development and automation of a novel [18F]Fprosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide

Morris, Olivia and Gregory, J. and Kadirvel, M. and Henderson, Fiona and Blykers, A. and McMahon, Adam and Taylor, Mark Neville and Allsop, David and Allan, Stuart and Grigg, J. and Boutin, Herve and Prenant, Christian (2016) Development and automation of a novel [18F]Fprosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide. Applied Radiation and Isotopes, 116. pp. 120-127. ISSN 0969-8043

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Abstract

2-[18F]-Fluoro-3-pyridinecarboxaldehyde ([18F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer's Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [18F]RI-OR2-TAT has been measured in Wistar rats.

Item Type:
Journal Article
Journal or Publication Title:
Applied Radiation and Isotopes
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3100/3108
Subjects:
ID Code:
80612
Deposited By:
Deposited On:
16 Aug 2016 10:10
Refereed?:
Yes
Published?:
Published
Last Modified:
07 Apr 2020 04:02