Genetic influences on schizophrenia and subcortical brain volumes:large-scale proof of concept

Franke, Barbara and Stein, Jason L. and Ripke, Stephan and Anttila, Verneri and Hibar, Derrek P. and van Hulzen, Kimm J. E. and Arias-Vasquez, Alejandro and Smoller, Jordan W. and Nichols, Thomas E. and Neale, Michael C. and McIntosh, Andrew M. and Lee, Phil and McMahon, Francis J. and Meyer-Lindenberg, Andreas and Mattheisen, Manuel and Andreassen, Ole A. and Gruber, Oliver and Sachdev, Perminder S. and Roiz-Santiañez, Roberto and Saykin, Andrew J. and Ehrlich, Stefan and Mather, Karen A. and Turner, Jessica A. and Schwarz, Emanuel and Thalamuthu, Anbupalam and Yao, Yin and Ho, Yvonne Y. W. and Martin, Nicholas G. and Wright, Margaret J. and O'Donovan, Michael C. and Thompson, Paul M. and Neale, Benjamin M. and Medland, Sarah E. and Sullivan, Patrick F. and Knight, Jo (2016) Genetic influences on schizophrenia and subcortical brain volumes:large-scale proof of concept. Nature Reviews Neuroscience, 19 (3). pp. 420-431. ISSN 1471-003X

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Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.

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Journal Article
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Nature Reviews Neuroscience
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© 2016 Macmillan Publishers Limited, part of Springer Nature.
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15 Jun 2016 09:04
Last Modified:
14 Sep 2020 01:45