An investigation of candidate regions for association with bipolar disorder

Knight, Jo and Rochberg, Nanette S. and Saccone, Scott F. and Nurnberger, John I. and Rice, John P. and , NIMH Genetics Initiative Bipolar Disorder Consortium (2010) An investigation of candidate regions for association with bipolar disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 153B (7). pp. 1292-1297. ISSN 1552-4841

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Abstract

We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105-113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2 × 10(-5)). Both P-values are in the top 5% of the distribution derived from null simulations (P = 0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP.

Item Type:
Journal Article
Journal or Publication Title:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2738
Subjects:
ID Code:
79940
Deposited By:
Deposited On:
07 Jun 2016 12:38
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Jan 2020 09:47