Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease

Hamilton, Gillian and Samedi, Farzana and Knight, Jo and Archer, Nicola and Foy, Catherine and Walter, Sarah and Turic, Dragana and Jehu, Luke and Moore, Pamela and Hollingworth, Paul and O'Donovan, Michael C. and Williams, Julie and Owen, Michael J. and Lovestone, Simon and Powell, John F. (2006) Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease. Neuroscience Letters, 401 (1-2). pp. 77-80. ISSN 0304-3940

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Abstract

The varepsilon4 allele of the APOE locus is the only confirmed risk factor for late-onset Alzheimer's disease (LOAD). The phosphate and tensin homolog (PTEN) gene is both a biological and positional candidate gene for LOAD. Eight polymorphisms spanning this gene were selected from dbSNP and genotyped in pooled DNA samples of both cases and controls. No evidence for association with LOAD was obtained in this study although further investigation revealed low levels of linkage disequlibrium (LD) between the genotyped SNPs. Our results suggest that it is unlikely that genetic variation within the PTEN gene contributes to risk of LOAD.

Item Type: Journal Article
Journal or Publication Title: Neuroscience Letters
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2800
Subjects:
Departments: Faculty of Arts & Social Sciences > Educational Research
ID Code: 79935
Deposited By: ep_importer_pure
Deposited On: 07 Jun 2016 12:52
Refereed?: Yes
Published?: Published
Last Modified: 11 Jun 2019 03:30
URI: https://eprints.lancs.ac.uk/id/eprint/79935

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