Association of the serotonin transporter gene, neuroticism and smoking behaviours

O'Gara, Colin and Knight, Jo and Stapleton, John and Luty, Jason and Neale, Ben and Nash, Matt and Heuzo-Diaz, Patricia and Hoda, Farzana and Cohen, Sarah and Sutherland, Gay and Collier, David and Sham, Pak and Ball, David and McGuffin, Peter and Craig, Ian (2008) Association of the serotonin transporter gene, neuroticism and smoking behaviours. Journal of Human Genetics, 53 (3). pp. 239-246. ISSN 1435-232X

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Cigarette consumption and smoking cessation are influenced in part by genes. Personality traits have also been implicated in the aetiology of smoking. Neuroticism, a personality trait with a heritable component, correlates well with anxiety and depression, increasing the risk of being a smoker and decreasing the chance of smoking cessation. Several prior studies in non-British populations have given conflicting results as to whether some genetic polymorphisms affect the relationship between smoking and neuroticism. This study investigated the influence of serotonin transporter (5HTTLPR) genotypes on a composite measure of neuroticism and cigarette consumption/smoking cessation in a British population. Although neuroticism was significantly associated with cigarette consumption and smoking cessation, genotype did not affect this relationship. Our results do not support initial interest in utilising 5HTTLPR genotypes in combination with neuroticism ratings for predicting outcome in smoking cessation clinical settings.

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Journal Article
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Journal of Human Genetics
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07 Jun 2016 15:36
Last Modified:
19 Sep 2023 01:35