The Bipolar Association Case-Control Study (BACCS) and meta-analysis:no association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder

Cohen-Woods, Sarah and Craig, Ian and Gaysina, Darya and Gray, Joanna and Gunasinghe, Cerisse and Craddock, Nick and Elkin, Amanda and Jones, Lisa and Kennedy, James and King, Nicole and Korszun, Ania and Knight, Jo and Owen, Michael and Parikh, Sagar and Strauss, John and Sterne, Abram and Tozzi, Federica and Perry, Julia and Muglia, Pierandrea and Vincent, John and McGuffin, Peter and Farmer, Anne (2010) The Bipolar Association Case-Control Study (BACCS) and meta-analysis:no association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 153B (7). pp. 1298-1304. ISSN 1552-4841

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Abstract

Bipolar disorder (BD) is a complex genetic disease for which the underlying pathophysiology has yet to be fully explained. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. A single base variant in MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme and has recently been implicated in BD. We conducted an association study of this polymorphism in 897 patients with bipolar I or bipolar II disorder, and 1,687 healthy control subjects. We found no evidence for genotypic or allelic association in this sample. We also performed a meta-analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD.

Item Type:
Journal Article
Journal or Publication Title:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2738
Subjects:
ID Code:
79894
Deposited By:
Deposited On:
08 Jun 2016 08:08
Refereed?:
Yes
Published?:
Published
Last Modified:
07 Apr 2020 03:56