The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa

Yilmaz, Zeynep and Kaplan, Allan S. and Tiwari, Arun K. and Levitan, Robert D. and Piran, Sara and Bergen, Andrew W. and Kaye, Walter H. and Hakonarson, Hakon and Wang, Kai and Berrettini, Wade H. and Brandt, Harry A. and Bulik, Cynthia M. and Crawford, Steven and Crow, Scott and Fichter, Manfred M. and Halmi, Katherine A. and Johnson, Craig L. and Keel, Pamela K. and Klump, Kelly L. and Magistretti, Pierre and Mitchell, James and Strober, Michael and Thornton, Laura M. and Treasure, Janet and Woodside, D. Blake and Knight, Joanne and Kennedy, James L. (2014) The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa. Journal of Psychiatric Research, 55. pp. 77-86. ISSN 0022-3956

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OBJECTIVE: Although low weight is a key factor contributing to the high mortality in anorexia nervosa (AN), it is unclear how AN patients sustain low weight compared with bulimia nervosa (BN) patients with similar psychopathology. Studies of genes involved in appetite and weight regulation in eating disorders have yielded variable findings, in part due to small sample size and clinical heterogeneity. This study: (1) assessed the role of leptin, melanocortin, and neurotrophin genetic variants in conferring risk for AN and BN; and (2) explored the involvement of these genes in body mass index (BMI) variations within AN and BN. METHOD: Our sample consisted of 745 individuals with AN without a history of BN, 245 individuals with BN without a history of AN, and 321 controls. We genotyped 20 markers with known or putative function among genes selected from leptin, melanocortin, and neurotrophin systems. RESULTS: There were no significant differences in allele frequencies among individuals with AN, BN, and controls. AGRP rs13338499 polymorphism was associated with lowest illness-related BMI in those with AN (p = 0.0013), and NTRK2 rs1042571 was associated with highest BMI in those with BN (p = 0.0018). DISCUSSION: To our knowledge, this is the first study to address the issue of clinical heterogeneity in eating disorder genetic research and to explore the role of known or putatively functional markers in genes regulating appetite and weight in individuals with AN and BN. If replicated, our results may serve as an important first step toward gaining a better understanding of weight regulation in eating disorders.

Item Type:
Journal Article
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Journal of Psychiatric Research
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Copyright © 2014 Elsevier Ltd. All rights reserved.
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08 Jun 2016 08:22
Last Modified:
22 Nov 2022 03:20