Distinguishing two isomeric mephedrone substitutes with selective reagent ionisation mass spectrometry (SRI-MS).

Lanza, Matteo and Acton, Joe and Jürschik, Simone and Sulzer, Philipp and Breiev, Kostiantyn and Jordan, Alfons and Hartungen, Eugen and Hanel, Gernot and Märk, Lukas and Mayhew, Chris A. and Märk, Tilmann D. (2013) Distinguishing two isomeric mephedrone substitutes with selective reagent ionisation mass spectrometry (SRI-MS). Journal of Mass Spectrometry, 48 (9). pp. 1015-1018. ISSN 1076-5174

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Abstract

The isomers 4-methylethcathinone and N-ethylbuphedrone are substitutes for the recently banned drug mephedrone. We find that with conventional proton transfer reaction mass spectrometry (PTR-MS), it is not possible to distinguish between these two isomers, because essentially for both substances, only the protonated molecules are observed at a mass-to-charge ratio of 192 (C12 H18 NO(+) ). However, when utilising an advanced PTR-MS instrument that allows us to switch the reagent ions (selective reagent ionisation) from H3 O(+) (which is commonly used in PTR-MS) to NO(+) , O2 (+) and Kr(+) , characteristic product (fragment) ions are detected: C4 H10 N(+) (72 Da) for 4-methylethcathinone and C5 H12 N(+) (86 Da) for N-ethylbuphedrone; thus, selective reagent ionisation MS proves to be a powerful tool for fast detection and identification of these compounds.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Mass Spectrometry
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1600/1607
Subjects:
ID Code:
79390
Deposited By:
Deposited On:
09 May 2016 09:34
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Jan 2020 09:43