Headspace analysis of new psychoactive substances using a Selective Reagent Ionisation-Time of Flight-Mass Spectrometer

Acton, Joe and Lanza, Matteo and Agarwal, Bishu and Jürschik, Simone and Sulzer, Philipp and Breiev, Kostiantyn and Jordan, Alfons and Hartungen, Eugen and Hanel, Gernot and Märk, Lukas and Mayhew, Chris A. and Märk, Tilmann D. (2014) Headspace analysis of new psychoactive substances using a Selective Reagent Ionisation-Time of Flight-Mass Spectrometer. International Journal of Mass Spectrometry, 360. pp. 28-38. ISSN 1387-3806

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Abstract

The rapid expansion in the number and use of new psychoactive substances presents a significant analytical challenge because highly sensitive instrumentation capable of detecting a broad range of chemical compounds in real-time with a low rate of false positives is required. A Selective Reagent Ionisation-Time of Flight-Mass Spectrometry (SRI-ToF-MS) instrument is capable of meeting all of these requirements. With its high mass resolution (up to m/Δm of 8000), the application of variations in reduced electric field strength (E/N) and use of different reagent ions, the ambiguity of a nominal (monoisotopic) m/z is reduced and hence the identification of chemicals in a complex chemical environment with a high level of confidence is enabled. In this study we report the use of a SRI-ToF-MS instrument to investigate the reactions of H3O+, O2+, NO+ and Kr+ with 10 readily available (at the time of purchase) new psychoactive substances, namely 4-fluoroamphetamine, methiopropamine, ethcathinone, 4-methylethcathinone, N-ethylbuphedrone, ethylphenidate, 5-MeO-DALT, dimethocaine, 5-(2-aminopropyl)benzofuran and nitracaine. In particular, the dependence of product ion branching ratios on the reduced electric field strength for all reagent ions was investigated and is reported here. The results reported represent a significant amount of new data which will be of use for the development of drug detection techniques suitable for real world scenarios.

Item Type: Journal Article
Journal or Publication Title: International Journal of Mass Spectrometry
Additional Information: Open Access funded by Biotechnology and Biological Sciences Research Council Under a Creative Commons license
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/3100/3104
Subjects:
Departments: Faculty of Science and Technology > Lancaster Environment Centre
ID Code: 79389
Deposited By: ep_importer_pure
Deposited On: 09 May 2016 10:12
Refereed?: Yes
Published?: Published
Last Modified: 24 Feb 2020 02:34
URI: https://eprints.lancs.ac.uk/id/eprint/79389

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