Structure-activity studies of tylosin-related macrolides

Fish, Steven Anthony (1996) Structure-activity studies of tylosin-related macrolides. Journal of Antibiotics, 49 (10). pp. 1044-1048.

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The effects of tylosin-related macrolide antibiotics were examined in cell-free protein synthesis (using a coupled transcription-translation system derived from Streptomyces lividans) and against whole cells of that organism. Anti-ribosomal potency was determined primarily by the number and nature of the glycosyl substituents, and was not significantly influenced by lactone ring oxidation or sugar methylation. In contrast, uptake of the drugs into S. lividans was influenced, either positively or negatively, by each of these structural parameters. The presence of erm type I or erm type II resistance genes in S. lividans markedly affected the resistance phenotype and studies involving ribosomes from such strains revealed differences in macrolide activity that were not otherwise apparent.

Item Type: Journal Article
Journal or Publication Title: Journal of Antibiotics
Departments: Faculty of Science and Technology > School of Computing & Communications
ID Code: 79374
Deposited By: ep_importer_pure
Deposited On: 06 May 2016 13:40
Refereed?: Yes
Published?: Published
Last Modified: 30 Sep 2019 19:19

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