DNA replication stress and cancer:cause or cure?

Taylor, Elaine Moira and Lindsay, Howard David (2016) DNA replication stress and cancer:cause or cure? Future Oncology, 12 (2). pp. 221-237. ISSN 1479-6694

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Abstract

There is an extensive and growing body of evidence that DNA replication stress is a major driver in the development and progression of many cancers, and that these cancers rely heavily on replication stress response pathways for their continued proliferation. This raises the possibility that the pathways that ordinarily protect cells from the accumulation of cancer-causing mutations may actually prove to be effective therapeutic targets for a wide range of malignancies. In this review, we explore the mechanisms by which sustained proliferation can lead to replication stress and genome instability, and discuss how the pattern of mutations observed in human cancers is supportive of this oncogene-induced replication stress model. Finally, we go on to consider the implications of replication stress both as a prognostic indicator and, more encouragingly, as a potential target in cancer treatment.

Item Type:
Journal Article
Journal or Publication Title:
Future Oncology
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2730
Subjects:
ID Code:
79260
Deposited By:
Deposited On:
28 Apr 2016 08:56
Refereed?:
Yes
Published?:
Published
Last Modified:
27 Sep 2020 03:07