Synthesis and characterization of biodegradable hydrogels for oral delivery of 5-fluorouracil targeted to colon:screening with preliminary in vivo studies

Minhas, Muhammad Usman and Ahmad, Mahmood and Anwar, Jamshed and Khan, Shahzeb (2018) Synthesis and characterization of biodegradable hydrogels for oral delivery of 5-fluorouracil targeted to colon:screening with preliminary in vivo studies. Advances in Polymer Technology, 37 (1). pp. 221-229. ISSN 0730-6679

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Abstract

In this communication, we developed a thermally stable, biocompatible, and colonically degradable hydrogel-based device [pectin-co-poly(MAA)] for oral delivery of 5-fluorouracil (5-FU) to treat colon cancer with minimal upper gastrointestinal invasion. Toward this end, ethylene glycol dimethacrylate (EGDMA) cross-linked hydrogels of pectin were synthesized. Methacrylic acid (MAA) was grafted to impart pH-responsive character, whereas benzoyl peroxide (BPO) was applied for simultaneous grafting and cross-linking polymerization. The hydrogels were characterized by Fourier transform infrared , thermogravimetric analysis, differential scanning calorimetry, and X-ray diffractometry. Scanning electron microscopic photographs were taken to analyze the surface morphology. Swelling behavior was analyzed to assess better performance of biodegradable hydrogels for optimized loading and release of the drug targeted to the colon. Gel fraction, swelling ratio, diffusion coefficient, drug loading, and cumulative release increased with an increase of pectin ratio and decreased with an increase of MAA and EGDMA ratio. Strategically, hydrogels with higher amounts of pectin were prepared for complete degradation in the colon. Our investigations indicate that pectin-co-poly(MAA) hydrogel is a suitable delivery system developed for oral delivery of the drug targeted to the colon.

Item Type:
Journal Article
Journal or Publication Title:
Advances in Polymer Technology
Additional Information:
This is the peer reviewed version of the following article: Minhas, M. U., Ahmad, M., Anwar, J. and Khan, S. (2018), Synthesis and Characterization of Biodegradable Hydrogels for Oral Delivery of 5-Fluorouracil Targeted to Colon: Screening with Preliminary In Vivo Studies. Adv. Polym. Technol., 37: 221–229. doi:10.1002/adv.21659 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/adv.21659/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1500
Subjects:
ID Code:
79185
Deposited By:
Deposited On:
09 May 2016 12:22
Refereed?:
Yes
Published?:
Published
Last Modified:
27 Nov 2020 03:43