Selective reagent ionisation-time of flight-mass spectrometry:a rapid technology for the novel analysis of blends of new psychoactive substances

Lanza, Matteo and Acton, Joe and Sulzer, Philipp and Breiev, Kostiantyn and Jürschik, Simone and Jordan, Alfons and Hartungen, Eugen and Hanel, Gernot and Märk, Lukas and Märk, Tilmann and Mayhew, Chris A. (2015) Selective reagent ionisation-time of flight-mass spectrometry:a rapid technology for the novel analysis of blends of new psychoactive substances. Journal of Mass Spectrometry, 50 (2). pp. 427-431. ISSN 1076-5174

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Abstract

In this study we demonstrate the potential of selective reagent ionisation-time of flight-mass spectrometry for the rapid and selective identification of a popular new psychoactive substance blend called ‘synthacaine’, a mixture that is supposed to imitate the sensory and intoxicating effects of cocaine. Reactions with H3O+ result in protonated parent molecules which can be tentatively assigned to benzocaine and methiopropamine. However, by comparing the product ion branching ratios obtained at two reduced electric field values (90 and 170 Td) for two reagent ions (H3O+ and NO+) to those of the pure chemicals, we show that identification is possible with a much higher level of confidence then when relying solely on the m/z of protonated parent molecules. A rapid and highly selective analytical identification of the constituents of a recreational drug is particularly crucial to medical personnel for the prompt medical treatment of overdoses, toxic effects or allergic reactions.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Mass Spectrometry
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1600/1607
Subjects:
ID Code:
79141
Deposited By:
Deposited On:
20 Apr 2016 13:18
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Jul 2020 02:49