Organic electronic materials for gene delivery

Hardy, John George (2016) Organic electronic materials for gene delivery. In: Engineering of nanobiomaterials. Elsevier, pp. 119-144. ISBN 9780323417341

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Abstract

Gene therapy has the potential to treat various diseases by altering levels of protein expression, or correcting genetic mutations. A prerequisite of effective gene is the delivery of polynucleic acids (e.g., DNA, RNA) to a patient’s cells which can be achieved by a variety of means, including technological (e.g., electroporation), viruses (which are nature’s gene delivery vectors) or non-viral vectors (e.g., lipids, nanoparticles, polymers). The focus of this chapter is the use of organic electronic materials (i.e., fullerenes, graphenes and conjugated polymers) as non-viral gene delivery vectors and their potential for application as novel theranostic devices. These represent an exciting new class of non-viral vectors that are at the frontier of novel approaches towards gene therapy.

Item Type:
Contribution in Book/Report/Proceedings
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2500/2502
Subjects:
ID Code:
79015
Deposited By:
Deposited On:
12 Apr 2016 08:08
Refereed?:
No
Published?:
Published
Last Modified:
19 Aug 2020 06:44