Long-term treatment with haloperidol affects neuropeptide S and NPSR mRNA levels in the rat brain

Palasz, Artur and Rojczyk, Ewa and Golyszny, Milosz and Filipczyk, Lukasz and Worthington, John J. and Wiaderkiewicz, Ryszard (2016) Long-term treatment with haloperidol affects neuropeptide S and NPSR mRNA levels in the rat brain. Acta Neuropsychiatrica, 28 (2). pp. 110-116. ISSN 0924-2708

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OBJECTIVE: The brainstem-derived neuropeptide S (NPS) has a multidirectional regulatory activity, especially as a potent anxiolytic factor. Accumulating data suggests that neuroleptics affect peptidergic signalling in various brain structures. However, there is no information regarding the influence of haloperidol on NPS and NPS receptor (NPSR) expression. METHODS: We assessed NPS and NPSR mRNA levels in brains of rats treated with haloperidol using quantitative real-time polymerase chain reaction. RESULTS: Chronic haloperidol treatment (4 weeks) led to a striking upregulation of NPS and NPSR expression in the rat brainstem. Conversely, the NPSR mRNA expression was decreased in the hippocampus and striatum. CONCLUSIONS: This stark increase of NPS in response to haloperidol treatment supports the hypothesis that this neuropeptide is involved in the dopamine-dependent anxiolytic actions of neuroleptics and possibly also in the pathophysiology of mental disorders. Furthermore, our findings underline the complex nature of potential interactions between dopamine receptors and brain peptidergic pathways, which has potential clinical applications.

Item Type:
Journal Article
Journal or Publication Title:
Acta Neuropsychiatrica
Additional Information:
http://journals.cambridge.org/action/displayJournal?jid=NEU The final, definitive version of this article has been published in the Journal, Acta Neuropsychiatrica, 28 (2), pp 110-116 2016, © 2016 Cambridge University Press.
Uncontrolled Keywords:
?? brainstemhaloperidolneurolepticsnpsrpsychiatry and mental healthbiological psychiatry ??
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Deposited On:
04 May 2016 13:18
Last Modified:
31 Dec 2023 00:40