Disease evolution on networks:the role of contact structure

Read, Jonathan M. and Keeling, Matt J. (2003) Disease evolution on networks:the role of contact structure. Proceedings of the Royal Society B: Biological Sciences, 270 (1516). pp. 699-708. ISSN 0962-8452

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Abstract

Owing to their rapid reproductive rate and the severe penalties for reduced fitness, diseases are under immense evolutionary pressure. Understanding the evolutionary response of diseases in new situations has clear public-health consequences, given the changes in social and movement patterns over recent decades and the increased use of antibiotics. This paper investigates how a disease may adapt in response to the routes of transmission available between infected and susceptible individuals. The potential transmission routes are defined by a computer-generated contact network, which we describe as either local (highly clustered networks where connected individuals are likely to share common contacts) or global (unclustered networks with a high proportion of long-range connections). Evolution towards stable strategies operates through the gradual random mutation of disease traits (transmission rate and infectious period) whenever new infections occur. In contrast to mean-field models, the use of contact networks greatly constrains the evolutionary dynamics. In the local networks, high transmission rates are selected for, as there is intense competition for susceptible hosts between disease progeny. By contrast, global networks select for moderate transmission rates because direct competition between progeny is minimal and a premium is placed upon persistence. All networks show a very slow but steady rise in the infectious period.

Item Type: Journal Article
Journal or Publication Title: Proceedings of the Royal Society B: Biological Sciences
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2700
Subjects:
Departments: Faculty of Health and Medicine > Medicine
ID Code: 78648
Deposited By: ep_importer_pure
Deposited On: 10 Mar 2016 09:56
Refereed?: Yes
Published?: Published
Last Modified: 22 Jun 2019 07:22
URI: https://eprints.lancs.ac.uk/id/eprint/78648

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