Hungerford, D. and Read, Jonathan M. and Cooke, R. P. D. and Vivancos, R. and Iturriza-Gómara, M. and Allen, D. J. and French, N. and Cunliffe, N. (2016) Early impact of rotavirus vaccination in a large paediatric hospital in the UK. Journal of Hospital Infection, 93 (2). pp. 117-120. ISSN 0195-6701
20160601_JHI_final_paper_repository_1_.pdf - Accepted Version
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Abstract
The impact of routine rotavirus vaccination on community-acquired (CA) and healthcare-associated (HA) rotavirus gastroenteritis (RVGE) at a large paediatric hospital, UK, was investigated over a 13-year period. A total of 1644 hospitalized children aged 0-15 years tested positive for rotavirus between July 2002 and June 2015. Interrupted time-series analysis demonstrated that, post vaccine introduction (July 2013 to June 2015), CA- and HA-RVGE hospitalizations were 83% [95% confidence interval (CI): 72-90%) and 83% (95% CI: 66-92%] lower than expected, respectively. Rotavirus vaccination has rapidly reduced the hospital rotavirus disease burden among both CA- and HA-RVGE cases.