Early impact of rotavirus vaccination in a large paediatric hospital in the UK

Hungerford, D. and Read, Jonathan M. and Cooke, R. P. D. and Vivancos, R. and Iturriza-Gómara, M. and Allen, D. J. and French, N. and Cunliffe, N. (2016) Early impact of rotavirus vaccination in a large paediatric hospital in the UK. Journal of Hospital Infection, 93 (2). pp. 117-120. ISSN 0195-6701

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Abstract

The impact of routine rotavirus vaccination on community-acquired (CA) and healthcare-associated (HA) rotavirus gastroenteritis (RVGE) at a large paediatric hospital, UK, was investigated over a 13-year period. A total of 1644 hospitalized children aged 0-15 years tested positive for rotavirus between July 2002 and June 2015. Interrupted time-series analysis demonstrated that, post vaccine introduction (July 2013 to June 2015), CA- and HA-RVGE hospitalizations were 83% [95% confidence interval (CI): 72-90%) and 83% (95% CI: 66-92%] lower than expected, respectively. Rotavirus vaccination has rapidly reduced the hospital rotavirus disease burden among both CA- and HA-RVGE cases.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Hospital Infection
Additional Information:
Copyright © 2016 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2726
Subjects:
ID Code:
78642
Deposited By:
Deposited On:
22 Jun 2016 08:50
Refereed?:
Yes
Published?:
Published
Last Modified:
18 Sep 2020 02:46