Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery

Hardy, John George and Larraneta, Eneko and Donnelly, Ryan and McGoldrick, Niamh and Migalska, Katarzyna and McCrudden, Maeliosa and Donnelly, Louise and McCoy, Colin (2016) Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery. Molecular Pharmaceutics, 13 (3). pp. 907-914. ISSN 1543-8392

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We describe, for the first time, stimuli-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically-relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) by micromolding. The obtained MN arrays showed good mechanical properties. The system was loaded with up to 5% (w/w) ibuprofen included in a light-responsive 3,5-dimethoxybenzoin conjugate. Raman spectroscopy confirmed the presence of the conjugate inside the polymeric MN matrix. In vitro, this system was able to deliver up to three doses of 50 mg of ibuprofen upon application of an optical trigger over a prolonged period of time (up to 160 hours). This makes the system appealing as a controlled release device for prolonged periods of time. We believe that this technology has potential for use in “on-demand” delivery of a wide range of drugs in a variety of applications relevant to enhanced patient care.

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Journal Article
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Molecular Pharmaceutics
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Copyright of ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in Molecular Pharmaceutics, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.5b00807
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27 Jan 2016 11:36
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27 Jun 2022 15:45