Extracellular matrix proteins and chemoradiotherapy:alpha5beta1 integrin as a predictive marker in rectal cancer

Jayne, D. G. and Heath, R. M. and Dewhurst, O. and Scott, N. and Guillou, P. J. (2002) Extracellular matrix proteins and chemoradiotherapy:alpha5beta1 integrin as a predictive marker in rectal cancer. European Journal of Surgical Oncology : The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 28 (1). pp. 30-36. ISSN 0748-7983

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Abstract

AIMS: To investigate the effects of extracellular matrix (ECM) protein expression on the rates of apoptosis and proliferation in rectal cancers and subsequent response to chemoradiotherapy (CRT). METHODS: The expression of fibronectin, collagen IV, laminin and the fibronectin receptor (FnR, alpha5beta1 integrin) were analysed in 32 pre-treatment rectal cancer biopsies by immunohistochemistry. ECM expression was correlated with tumour mitotic index (MI), apoptotic index (AI) and histopathological response to CRT. RESULTS: 18/32 cancers showed a poor response and 14/32 a good response (5/14 with complete pathological response) to CRT. Moderate to strong staining was seen in 22/32 cancers for fibronectin, 5/32 for collagen IV and 18/32 for laminin. Tumour FnR was related to stromal fibronectin content, and was significantly associated with CRT response; good responders having higher FnR expression compared to poor responders. No association was found between FnR expression and either MI or AI in pre-treatment biopsies, nor between MI or AI and CRT response. CONCLUSIONS: Tumour FnR expression is independent of MI and AI, and may serve as a useful marker for CRT response in rectal cancer.

Item Type:
Journal Article
Journal or Publication Title:
European Journal of Surgical Oncology : The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Additional Information:
Copyright Harcourt Publishers Limited.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2730
Subjects:
ID Code:
77572
Deposited By:
Deposited On:
07 Jan 2016 14:40
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Jan 2020 07:57