Adult height, coronary heart disease and stroke:a multi-locus Mendelian randomization meta-analysis

Nüesch, Eveline and Dale, Caroline and Palmer, Tom M. and White, Jon and Keating, Brendan J. and van Iperen, Erik P. A. and Goel, Anuj and Padmanabhan, Sandosh and Asselbergs, Folkert W. and Verschuren, W. M. and Wijmenga, C. and Van der Schouw, Y. T. and Onland-Moret, N. C. and Lange, Leslie A. and Hovingh, G. Kees and Sivapalaratnam, Suthesh and Morris, Richard W. and Whincup, Peter H. and Wannamethe, Goya S. and Gaunt, Tom R. and Ebrahim, Shah and Steel, Laura and Nair, Nikhil and Reiner, Alexander P. and Kooperberg, Charles and Wilson, James F. and Bolton, Jennifer L. and McLachlan, Stela and Price, Jacqueline F. and Strachan, Mark W. J. and Robertson, Christine M. and Kleber, Marcus E. and Delgado, Graciela and März, Winfried and Melander, Olle and Dominiczak, Anna F. and Farrall, Martin and Watkins, Hugh and Leusink, Maarten and Maitland-van der Zee, Anke H. and de Groot, Mark C. H. and Dudbridge, Frank and Hingorani, Aroon and Ben-Shlomo, Yoav and Lawlor, Debbie A. and Amuzu, A. and Caufield, M. and Cavadino, A. and Cooper, J. and Davies, T. L. (2016) Adult height, coronary heart disease and stroke:a multi-locus Mendelian randomization meta-analysis. International Journal of Epidemiology, 45 (6). pp. 1927-1937. ISSN 0300-5771

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Background: We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis.Methods: We developed an allele score based on 69 single nucleotide polymorphisms (SNPs) associated with adult height, identified by the IBCCardioChip, and used it for IV analysis against cardiovascular risk factors and events in 21 studies and 60 028 participants. IV analysis on CHD was supplemented by summary data from 180 height-SNPs from the GIANT consortium and their corresponding CHD estimates derived from CARDIoGRAMplusC4D.Results: IV estimates from IBCCardioChip and GIANT-CARDIoGRAMplusC4D showed that a 6.5-cm increase in height reduced the odds of CHD by 10% [odds ratios 0.90; 95% confidence intervals (CIs): 0.78 to 1.03 and 0.85 to 0.95, respectively],which agrees with the estimate from the Emerging Risk Factors Collaboration (hazard ratio 0.93; 95% CI: 0.91 to 0.94). IV analysis revealed no association with stroke (odds ratio 0.97; 95% CI: 0.79 to 1.19). IV analysis showed that a 6.5-cm increase in height resulted in lower levels of body mass index (P

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Journal Article
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International Journal of Epidemiology
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24 Nov 2015 09:50
Last Modified:
11 Jun 2020 04:07