Novel tertiary amine oxide surfaces that resist nonspecific protein adsorption

Dilly, Suzanne J. and Beecham, Matthew P. and Brown, Steven P. and Griffin, John M. and Clark, Andrew J. and Griffin, Craig D. and Marshall, Jacqueline and Napier, Richard M. and Taylor, Paul C. and Marsh, Andrew (2006) Novel tertiary amine oxide surfaces that resist nonspecific protein adsorption. Langmuir, 22 (19). pp. 8144-8150. ISSN 0743-7463

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Novel surfaces derivatized with tertiary amine oxides have been prepared and tested for their ability to resist nonspecific protein adsorption. The oxidation of tertiary amines supported on triazine units was carried out using mCPBA to give a format allowing conjugation of biologically active ligands alongside them. Adsorption to these surfaces was tested and compared to adsorption to a set of commercial and custom oligo-/poly(ethylene glycol) (OEG/PEG) supports by challenging them with a protein display library presented on bacteriophage I. The new class of amine oxide surfaces is found to compare favorably with the performance of the OEG/PEG supports in the prevention of nonspecific binding.

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28 Sep 2015 15:56
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22 Nov 2022 02:17