Griffin, John M. and Martin, Dave R. and Brown, Steven P. (2007) Distinguishing anhydrous and hydrous forms of an active pharmaceutical ingredient in a tablet formulation using solid-state NMR spectroscopy. Angewandte Chemie International Edition, 46 (42). pp. 8036-8038. ISSN 1433-7851
Full text not available from this repository.Abstract
With or without water? In under two hours, an NMR spectroscopy experiment can determine whether the anhydrous form of an active pharmaceutical ingredient is present in a tablet formulation. Such a high-resolution spectrum constitutes a new analytical tool that should be routinely adopted in the characterization of pharmaceuticals.
Item Type:
Journal Article
Journal or Publication Title:
Angewandte Chemie International Edition
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1600/1600
Subjects:
?? analytical methodsdrug designnmr spectroscopypolymorphismproton-proton proximitiesh-1-h-1 double-quantumpolymorphismdynamicspulsegeneral chemistrycatalysischemistry(all) ??
ID Code:
75705
Deposited By:
Deposited On:
21 Oct 2015 04:58
Refereed?:
Yes
Published?:
Published
Last Modified:
16 Jul 2024 09:49