Supracolloidal assemblies as sacrificial templates for porous silk-based biomaterials

Hardy, John and Ghezzi, Chiara and Saballos, Richard and Kaplan, David L. and Schmidt, Prof. Christine E. (2015) Supracolloidal assemblies as sacrificial templates for porous silk-based biomaterials. International Journal of Molecular Sciences, 16 (9). pp. 20511-20522. ISSN 1661-6596

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Abstract

Tissues in the body are hierarchically structured composite materials with tissue-specific properties. Urea self-assembles via hydrogen bonding interactions into crystalline supracolloidal assemblies that can be used to impart macroscopic pores to polymer-based tissue scaffolds. In this communication, we explain the solvent interactions governing the solubility of urea and thereby the scope of compatible polymers. We also highlight the role of solvent interactions on the morphology of the resulting supracolloidal crystals. We elucidate the role of polymer-urea interactions on the morphology of the pores in the resulting biomaterials. Finally, we demonstrate that it is possible to use our urea templating methodology to prepare Bombyx mori silk protein-based biomaterials with pores that human dermal fibroblasts respond to by aligning with the long axis of the pores. This methodology has potential for application in a variety of different tissue engineering niches in which cell alignment is observed, including skin, bone, muscle and nerve.

Item Type:
Journal Article
Journal or Publication Title:
International Journal of Molecular Sciences
Additional Information:
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1700/1706
Subjects:
ID Code:
75442
Deposited By:
Deposited On:
17 Nov 2015 10:08
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Jul 2020 05:12