Electroactive tissue scaffolds with aligned pores as instructive platforms for biomimetic tissue engineering

Hardy, John G. and Cornelison, R. Chase and Sukhavasi, Rushi C. and Saballos, Richard J. and Vu, Philip and Kaplan, David L. and Schmidt, Christine E. (2015) Electroactive tissue scaffolds with aligned pores as instructive platforms for biomimetic tissue engineering. Bioengineering, 2 (1). pp. 15-34. ISSN 2306-5354

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Abstract

Tissues in the body are hierarchically structured composite materials with tissue-specific chemical and topographical properties. Here we report the preparation of tissue scaffolds with macroscopic pores generated via the dissolution of a sacrificial supramolecular polymer-based crystal template (urea) from a biodegradable polymer-based scaffold (polycaprolactone, PCL). Furthermore, we report a method of aligning the supramolecular polymer-based crystals within the PCL, and that the dissolution of the sacrificial urea yields scaffolds with macroscopic pores that are aligned over long, clinically-relevant distances (i.e., centimeter scale). The pores act as topographical cues to which rat Schwann cells respond by aligning with the long axis of the pores. Generation of an interpenetrating network of polypyrrole (PPy) and poly(styrene sulfonate) (PSS) in the scaffolds yields electroactive tissue scaffolds that allow the electrical stimulation of Schwann cells cultured on the scaffolds which increases the production of nerve growth factor (NGF).

Item Type:
Journal Article
Journal or Publication Title:
Bioengineering
Subjects:
ID Code:
75390
Deposited By:
Deposited On:
09 Sep 2015 06:32
Refereed?:
Yes
Published?:
Published
Last Modified:
28 Apr 2020 03:23