Biodegradable electroactive polymers for electrochemically-triggered drug delivery

Hardy, John G. and Mouser, David J. and Arroyo-Currás, Netzahualcóyotl and Geissler, Sydney and Chow, Jacqueline K. and Nguy, Lindsey and Kim, Jong M. and Schmidt, Christine E. (2014) Biodegradable electroactive polymers for electrochemically-triggered drug delivery. Journal of Materials Chemistry B, 2 (39). pp. 6809-6822. ISSN 2050-750X

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Abstract

We report biodegradable electroactive polymer (EAP)-based materials and their application as drug delivery devices. Copolymers composed of oligoaniline-based electroactive blocks linked to either polyethylene glycol or polycaprolactone blocks via ester bonds were synthesized in three steps from commercially available starting materials and isolated without the need for column chromatography. The physicochemical and electrochemical properties of the polymers were characterized with a variety of techniques. The ability of the polymers to deliver the anti-inflammatory drug dexamethasone phosphate on the application of electrochemical stimuli was studied spectroscopically. Films of the polymers were shown to be degradable and cell adhesive in vitro. Such EAP-based materials have prospects for integration in implantable fully biodegradable/bioerodible EAP-based drug delivery devices that are capable of controlling the chronopharmacology of drugs for future clinical application.

Item Type: Journal Article
Journal or Publication Title: Journal of Materials Chemistry B
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1600
Subjects:
ID Code: 75379
Deposited By: ep_importer_pure
Deposited On: 09 Sep 2015 06:32
Refereed?: Yes
Published?: Published
Last Modified: 29 Jan 2020 02:44
URI: https://eprints.lancs.ac.uk/id/eprint/75379

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