Glycopolymer functionalization of engineered spider silk protein-based materials for improved cell adhesion

Hardy, John G. and Pfaff, Andre and Leal-Egana, Aldo and Mueller, Axel H. E. and Scheibel, Thomas R. (2014) Glycopolymer functionalization of engineered spider silk protein-based materials for improved cell adhesion. Macromolecular Bioscience, 14 (7). pp. 936-942. ISSN 1616-5187

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Abstract

Silk protein-based materials are promising biomaterials for application as tissue scaffolds, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) and their functionalization with glycopolymers are described. The glycopolymers bind proteins found in the extracellular matrix, providing a biomimetic coating on the films that improves cell adhesion to the surfaces of engineered spider silk films. Such silk-based materials have potential as coatings for degradable implantable devices.

Item Type:
Journal Article
Journal or Publication Title:
Macromolecular Bioscience
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1305
Subjects:
ID Code:
75376
Deposited By:
Deposited On:
09 Sep 2015 06:32
Refereed?:
Yes
Published?:
Published
Last Modified:
11 Mar 2020 04:45