Mechanical properties of α-tricalcium phosphate-based bone cements incorporating regenerative biomaterials for filling bone defects exposed to low mechanical loads

Harrison, Reed and Criss, Zachary K. and Feller, Lacie and Modi, Shan P. and Hardy, John G. and Schmidt, Christine E. and Suggs, Laura J. and Murphy, Matthew B. (2016) Mechanical properties of α-tricalcium phosphate-based bone cements incorporating regenerative biomaterials for filling bone defects exposed to low mechanical loads. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 104 (1). pp. 149-157. ISSN 1552-4973

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Abstract

Calcium phosphate-based cements with enhanced regenerative potential are promising biomaterials for the healing of bone defects. With a view to the use of such cements for low load bearing applications such as sinus augmentation or filling extraction sites, we have prepared α-tricalcium phosphate (α-TCP)-based bone cements including materials that we would expect to improve their regenerative potential, and describe the mechanical properities of the resulting formulations herein. Formulations incorporated α-TCP, hydroxyapatite, biopolymer-thickened wetting agents, sutures, and platelet poor plasma. The mechanical properties of the composites were composition dependent, and optimized formulations had clinically relevant mechanical properties. Such calcium phosphate-based cements have potential as replacements for cements such as those based on polymethylmethacrylate (PMMA).

Item Type:
Journal Article
Journal or Publication Title:
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Additional Information:
This is the peer reviewed version of the following article: Chrisman, J. J., Fang, H., Kotlar, J. and De Massis, A. (2014), A Note on Family Influence and the Adoption of Discontinuous Technologies in Family Firms. Journal of Product Innovation Management. doi: 10.1111/jpim.12206 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/jpim.12206/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700
Subjects:
ID Code:
75375
Deposited By:
Deposited On:
09 Sep 2015 06:32
Refereed?:
Yes
Published?:
Published
Last Modified:
02 Jul 2020 02:01