Psychological interventions for adults with bipolar disorder : a systematic review and meta-analysis

Oud, Matthijs and Mayo-Wilson, Evan and Braidwood, Ruth and Schulte, Peter and Jones, Steven and Morriss, Richard and Kupka, Ralph and Cuijpers, Pim and Kendall, Tim (2016) Psychological interventions for adults with bipolar disorder : a systematic review and meta-analysis. British Journal of Psychiatry, 208 (3). pp. 213-222. ISSN 0007-1250

[thumbnail of Psychological_interventions_for_adults_with_bipolar_disorder]
PDF (Psychological_interventions_for_adults_with_bipolar_disorder)
Psychological_interventions_for_adults_with_bipolar_disorder.pdf - Accepted Version
Available under License Creative Commons Attribution-NonCommercial.

Download (149kB)


Background Psychological interventions may be beneficial in bipolar disorder. Aims To evaluate the efficacy of psychological interventions for adults with bipolar disorder. Method A systematic review of randomised controlled trials was conducted. Outcomes were meta-analysed using RevMan and confidence assessed using the GRADE method. Results We included 55 trials with 6010 participants. Moderate-quality evidence associated individual psychological interventions with reduced relapses at post-treatment (risk ratio (RR) = 0.66, 95% CI 0.48–0.92) and follow-up (RR = 0.74, 95% CI 0.63–0.87), and collaborative care with a reduction in hospital admissions (RR = 0.68, 95% CI 0.49–0.94). Low-quality evidence associated group interventions with fewer depression relapses at post-treatment and follow-up, and family psychoeducation with reduced symptoms of depression and mania. Conclusions There is evidence that psychological interventions are effective for people with bipolar disorder. Much of the evidence was of low or very low quality thereby limiting our conclusions. Further research should identify the most effective (and cost-effective) interventions for each phase of this disorder.

Item Type:
Journal Article
Journal or Publication Title:
British Journal of Psychiatry
Additional Information:
This is an author-produced electronic version of an article accepted for publication in the British Journal of Psychiatry. The definitive publisher-authenticated version is available online at
Uncontrolled Keywords:
?? psychiatry and mental health ??
ID Code:
Deposited By:
Deposited On:
02 Mar 2016 16:48
Last Modified:
28 Nov 2023 11:21