First isolation of a new species of Leishmania responsible for human cutaneous leishmaniasis in Ghana and classification in the Leishmania enriettii complex

Kwakye-Nuako, Godwin and Mosore, Mba-Tihssommah and Duplessis, Christopher and Bates, Michelle and Puplampu, Naiki and Mensah-Attipoe, Israel and Desewu, Kwame and Afegbe, Godwin and Asmah, Richard and Jamjoom, Manal and Ayeh-Kumi, Patrick and Boakye, Daniel and Bates, Paul (2015) First isolation of a new species of Leishmania responsible for human cutaneous leishmaniasis in Ghana and classification in the Leishmania enriettii complex. International Journal for Parasitology, 45 (11). pp. 679-684. ISSN 0020-7519

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Abstract

An active case detection approach with PCR diagnosis was used in the Ho District of the Volta Region, Ghana that identified individuals with active cutaneous leishmaniasis. Three isolates were successfully cultured and DNA sequences from these were analysed (ribosomal RNA internal transcribed spacer 1; ribosomal protein L23a intergenic spacer; RNA polymerase II large subunit), showing them to be Leishmania, identical to each other but different from all other known Leishmania spp. Phylogenetic analysis showed the parasites to be new members of the Leishmania enriettii complex, which is emerging as a possible new subgenus of Leishmania parasites containing human pathogens.

Item Type:
Journal Article
Journal or Publication Title:
International Journal for Parasitology
Additional Information:
This is the author’s version of a work that was accepted for publication in International Journal for Parasitology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Joural for Parasitology, 45, 11, 2015 DOI: 10.1016/j.ijpara.2015.05.001
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2400/2405
Subjects:
ID Code:
74048
Deposited By:
Deposited On:
18 Jun 2015 06:00
Refereed?:
Yes
Published?:
Published
Last Modified:
28 Nov 2020 03:03