Kunz, Cornelia and Kieser, Meinhard (2011) Simon’s minimax and optimal and Jung’s admissible two-stage design with or without curtailment. Stata Journal, 11 (2). pp. 240-254. ISSN 1536-867X
Full text not available from this repository.Abstract
This article describes a new Stata command called simontwostage, which calculates the critical values and sample sizes for two-stage designs for phase II oncology trials. Options are provided to determine the minimax and optimal designs proposed by Simon (1989, Controlled Clinical Trials 10: 1–10) and admissible designs described by Jung et al. (2004, Statistics in Medicine 23: 561–569). Furthermore, nonstochastic and stochastic curtailment rules can be implemented in both stages of the trial, and the properties of the curtailed designs can be examined.