Dynamic markers based on blood perfusion fluctuations for selecting skin melanocytic lesions for biopsy

Lancaster, Gemma and Stefanovska, Aneta and Pesce, Margherita and Vezzoni, Gian Marco and Loggini, Barbara and Pingitore, Raffaele and Ghiara, Fabrizio and Barachini, Paolo and Cervadoro, Gregorio and Romanelli, Marco and Rossi, Marco (2015) Dynamic markers based on blood perfusion fluctuations for selecting skin melanocytic lesions for biopsy. Scientific Reports, 5. ISSN 2045-2322

[img]
PDF (srep12825)
srep12825.pdf - Published Version
Available under License Creative Commons Attribution.

Download (1MB)
[img]
Preview
PDF (scirep13)
scirep13.pdf - Accepted Version
Available under License Creative Commons Attribution.

Download (796kB)

Abstract

Skin malignant melanoma is a highly angiogenic cancer, necessitating early diagnosis for positive prognosis. The current diagnostic standard of biopsy and histological examination inevitably leads to many unnecessary invasive excisions. Here, we propose a non-invasive method of identification of melanoma based on blood flow dynamics. We consider a wide frequency range from 0.005 – 2 Hz associated with both local vascular regulation and effects of cardiac pulsation. Combining uniquely the power of oscillations associated with individual physiological processes we obtain a marker which distinguishes between melanoma and atypical nevi with sensitivity of 100% and specificity of 90.9%. The method reveals valuable functional information about the melanoma microenvironment. It also provides the means for simple, accurate, in vivo distinction between malignant melanoma and atypical nevi, and may lead to a substantial reduction in the number of biopsies currently undertaken.

Item Type:
Journal Article
Journal or Publication Title:
Scientific Reports
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1000
Subjects:
ID Code:
73804
Deposited By:
Deposited On:
18 Jun 2015 05:45
Refereed?:
Yes
Published?:
Published
Last Modified:
08 Aug 2020 04:18