Multi-scale interaction of particulate flow and the artery wall

Halliday, I. and Atherton, M. and Care, C. M. and Collins, M. W. and Evans, David and Evans, P. C. and Hose, D. R. and Khir, A. W. and Konig, C. S. and Krams, R. and Lawford, P. V. and Lishchuk, S. V. and Pontrelli, G. and Ridger, V. and Spencer, T. J. and Ventikos, Y. and Walker, D. C. and Watton, P. N. (2011) Multi-scale interaction of particulate flow and the artery wall. Medical Engineering and Physics, 33 (7). pp. 840-848. ISSN 1350-4533

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Abstract

We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying the widely separated spatial and temporal scales which participate. We draw on current, related models of vessel wall evolution, paying particular attention to the role of particulate flow (blood is not a continuum fluid), and proceed to propose, then validate all the key components in a multiply-coupled, multi-scale modeling strategy (in qualitative terms only, note). Eventually, this strategy should lead to a quantitative, patient-specific understanding of the coupling between particulate flow and the endothelial state.

Item Type:
Journal Article
Journal or Publication Title:
Medical Engineering and Physics
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1304
Subjects:
ID Code:
73550
Deposited By:
Deposited On:
18 Jun 2015 05:38
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Jan 2020 09:11