The application of multiscale modelling to the process of development and prevention of stenosis in a stented coronary artery

Evans, David and Lawford, P. V. and Gunn, J. and Walker, D. and Hose, D. R. and Smallwood, R. H. and Chopard, B. and Krafczyk, M. and Bernsdorf, J. and Hoekstra, A. (2008) The application of multiscale modelling to the process of development and prevention of stenosis in a stented coronary artery. Philosophical Transactions of the Royal Society A: Mathematical, Physical & Engineering Sciences, 366 (1879). pp. 3343-3360. ISSN 1364-503X

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Abstract

The inherent complexity of biomedical systems is well recognized; they are multiscale, multiscience systems, bridging a wide range of temporal and spatial scales. While the importance of multiscale modelling in this context is increasingly recognized, there is little underpinning literature on the methodology and generic description of the process. The COAST (complex autonoma simulation technique) project aims to address this by developing a multiscale, multiscience framework, coined complex autonoma (CxA), based on a hierarchical aggregation of coupled cellular automata (CA) and agent-based models (ABMs). The key tenet of COAST is that a multiscale system can be decomposed into N single-scale CA or ABMs that mutually interact across the scales. Decomposition is facilitated by building a scale separation map on which each single-scale system is represented according to its spatial and temporal characteristics. Processes having well-separated scales are thus easily identified as the components of the multiscale model. This paper focuses on methodology, introduces the concept of the CxA and demonstrates its use in the generation of a multiscale model of the physical and biological processes implicated in a challenging and clinically relevant problem, namely coronary artery in-stent restenosis.

Item Type:
Journal Article
Journal or Publication Title:
Philosophical Transactions of the Royal Society A: Mathematical, Physical & Engineering Sciences
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2600
Subjects:
ID Code:
73547
Deposited By:
Deposited On:
18 Jun 2015 05:38
Refereed?:
Yes
Published?:
Published
Last Modified:
03 Mar 2020 08:38