Substituted dipyridophenazine complexes of Cr(III):synthesis, enantiomeric resolution and binding interactions with calf thymus DNA (vol 39, pg 3990, 2010)

Vasudevan, S. and Smith, J. A. and Wojdyla, M. and DiTrapani, A. and Kruger, P. E. and McCabe, T. and Fletcher, N. C. and Quinn, S. J. and Kelly, J. M. (2010) Substituted dipyridophenazine complexes of Cr(III):synthesis, enantiomeric resolution and binding interactions with calf thymus DNA (vol 39, pg 3990, 2010). Dalton Transactions, 39 (48). p. 11687. ISSN 1477-9226

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Abstract

[Cr(phen)2(X2dppz)]3+ {X = H, Me, or F} have been synthesised, characterised, and chromatographically resolved into their constituent Δ and Λ enantiomers. The DNA-binding interactions of each of the racemic complexes were investigated, with the results of linear dichroism, thermal denaturation, and emission quenching studies indicative of intercalative binding to CT-DNA with a significant electrostatic contribution. UV/Vis absorption titrations suggest strong DNA binding by each of the racemic complexes, with the methylated analogue [Cr(phen)2(Me2dppz)]3+ exhibiting the largest equilibrium binding constant. Emission quenching and UV-Vis titrations of the enantiomers of [Cr(phen)2(dppz)]3+ imply similar binding affinities for the Δ and Λ isomers, although significant differences between the circular dichroism spectra of the enantiomers in the presence of DNA connote differences in binding orientation and/or conformation between the two.

Item Type:
Journal Article
Journal or Publication Title:
Dalton Transactions
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1600/1604
Subjects:
ID Code:
72392
Deposited By:
Deposited On:
22 Jan 2015 10:13
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Jan 2020 09:06