Raman spectroscopy for forensic examination of beta-ketophenethylamine "legal highs":reference and seized samples of cathinone derivatives

Stewart, Samantha P. and Bell, Steven E. J. and Fletcher, Nicholas C. and Bouazzaoui, Samira and Ho, Yen Cheng and Speers, S. James and Peters, K. Laota (2012) Raman spectroscopy for forensic examination of beta-ketophenethylamine "legal highs":reference and seized samples of cathinone derivatives. Analytica Chimica Acta, 711. pp. 1-6. ISSN 0003-2670

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Abstract

Raman spectra of a representative range of beta-ketophenethylamine (beta-KP), the rapidly growing family of cathinone-related "legal high" recreational drugs, have been recorded. These spectra showed characteristic changes that were associated with the pattern of substitution on the aromatic rings, for example, the compounds carrying substituents at the 4- position could be distinguished from 3,4-methylenedioxy "ecstasy" derivatives. They also showed small but detectable changes with differences in substitution on the ethylamine substituent. These features allowed the beta-KPs present in seized casework samples to be identified. The seized samples typically contained only small amounts of bulking agents, which meant that the band intensities of these components within averaged data were very small. In contrast, grid sampling normally gave at least some spectra which had a higher than average proportion of the bulking agent(s), which allowed them to also be identified. This study therefore demonstrates that Raman spectroscopy can be used both to provide a rapid, non-destructive technique for identification of this class of drugs in seized samples and to detect minor constituents, giving a composition profile which can be used for drugs intelligence work. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.

Item Type:
Journal Article
Journal or Publication Title:
Analytica Chimica Acta
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1600/1602
Subjects:
ID Code:
72388
Deposited By:
Deposited On:
22 Jan 2015 10:13
Refereed?:
Yes
Published?:
Published
Last Modified:
20 Oct 2020 03:09