Exploiting Sm(II) and Sm(III) in SmI2-initiated reaction cascades:application in a tag removal-cyclisation approach to spirooxindole scaffolds

Coote, Susannah C. and Quenum, Seidjolo and Procter, David J. (2011) Exploiting Sm(II) and Sm(III) in SmI2-initiated reaction cascades:application in a tag removal-cyclisation approach to spirooxindole scaffolds. Organic and Biomolecular Chemistry, 9 (14). pp. 5104-5108. ISSN 1477-0520

Full text not available from this repository.

Abstract

A tag removal-cyclisation sequence is described that is initiated by reduction using a Sm(II) species and completed by a Sm(III) Lewis acid that is formed in an earlier stage. Therefore, the reaction cascade utilises both oxidation states of a samarium reagent in discrete steps and allows access to privileged, pyrrolidinyl-spirooxindole scaffolds and analogues inspired by the anti-cancer natural product spirotryprostatin A.

Item Type:
Journal Article
Journal or Publication Title:
Organic and Biomolecular Chemistry
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1600/1606
Subjects:
ID Code:
72305
Deposited By:
Deposited On:
05 Jan 2015 11:32
Refereed?:
Yes
Published?:
Published
Last Modified:
07 Jan 2020 04:08