Expedient approach to chiral cyclobutanones : asymmetric synthesis of cyclobut-G

Darses, Benjamin and Greene, Andrew E. and Coote, Susannah C. and Poisson, Jean-Francois (2008) Expedient approach to chiral cyclobutanones : asymmetric synthesis of cyclobut-G. Organic Letters, 10 (5). pp. 821-824. ISSN 1523-7060

Abstract

An efficient one-pot asymmetric synthesis of cyclobutanones from chiral enol ethers is described. The approach is illustrated with alkyl- and functionalized alkyl-substituted enol ethers (nine examples). A new enantioselective synthesis of cyclobut-G (Lobucavir) could thus be achieved.