Graphene sculpturene nanopores for DNA nucleobase sensing

Sadeghi, Hatef and Algaragholy, L. and Pope, T. and Bailey, S. and Visontai, D. and Manrique, D. and Ferrer, J. and Garcia-Suarez, V. and Sangtarash, Sara and Lambert, Colin J. (2014) Graphene sculpturene nanopores for DNA nucleobase sensing. Journal of Physical Chemistry B, 118 (24). pp. 6908-6914. ISSN 1520-6106

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To demonstrate the potential of nanopores in bilayer graphene for DNA sequencing, we computed the current-voltage characteristics of a bilayer graphene junction containing a nanopore and found that they change significantly when nucleobases are transported through the pore. To demonstrate the sensitivity and selectivity of example devices, we computed the probability distribution P-X(beta) of the quantity beta representing the change in the logarithmic current through the pore due to the presence of a nucleobase X (X = adenine, thymine, guanine, or cytosine). We quantified the selectivity of the bilayer-graphene nanopores by showing that P-X(beta) exhibits distinct peaks for each base X. To demonstrate that such discriminating sensing is a general feature of bilayer nanopores, the well-separated positions of these peaks were shown to be present for different pores, with alternative examples of electrical contacts.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Physical Chemistry B
?? solid-state nanoporeselectrochemical sensorsequencing technologiessensitive detectioncarbon nanotubesbiosensorssingletranslocationgenerationschallenges ??
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15 Dec 2014 12:15
Last Modified:
17 Dec 2023 01:29