Nevasic audio program for the prevention of chemotherapy induced nausea and vomiting:a feasibility study using a randomized controlled trial design

Moradian, Saeed and Walshe, Catherine and Shahidsales, Soodabeh and Ghavam Nasiri, Moammad Reza and Pilling, Mark and Molassiotis, Alex (2015) Nevasic audio program for the prevention of chemotherapy induced nausea and vomiting:a feasibility study using a randomized controlled trial design. European Journal of Oncology Nursing, 19 (3). pp. 282-291. ISSN 1462-3889

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Abstract

Purpose Pharmacological therapy is only partially effective in preventing or treating chemotherapy induced nausea and vomiting (CINV). Therefore, exploring the complementary role of non-pharmacological approaches used in addition to pharmacological agents is important. Nevasic uses specially constructed audio signals hypothesized to generate an antiemetic reaction. The aim of this study was to examine the feasibility of conducting a randomized controlled trial (RCT) to evaluate the effectiveness of Nevasic to control CINV. Methods A mixed methods design incorporating an RCT and focus group interviews. For the RCT, female breast cancer patients were randomized to receive either Nevasic plus usual care, music plus usual care, or usual care only. Data were analyzed using descriptive statistics and linear mixed-effects models. Five focus group interviews were conducted to obtain participants’ views regarding the acceptability of the interventions in the trial. Results 99 participants were recruited to the RCT and 15 participated in focus group interviews. Recruitment targets were achieved. Issues of Nevasic acceptability were highlighted as weaknesses of the program. This study did not detect any evidence for the effectiveness of Nevasic; however, the results showed statistically significant less use of anti-emetics (p=0.003) and borderline non-significant improvement in quality of life (p=0.06). Conclusions Conducting a non-pharmacological intervention using such an audio program is feasible, although difficulties and limitations exist with its use. Further studies are required to investigate the effectiveness of Nevasic from perspectives such as anti-emetic use, as well as its overall effect on the levels of nausea and vomiting.

Item Type:
Journal Article
Journal or Publication Title:
European Journal of Oncology Nursing
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2900/2917
Subjects:
ID Code:
72122
Deposited By:
Deposited On:
11 Dec 2014 09:06
Refereed?:
Yes
Published?:
Published
Last Modified:
09 Sep 2020 02:28