First isolation of Leishmania from Northern Thailand:case report, identification as Leishmania martiniquensis and phylogenetic position within the Leishmania enriettii complex

Pothirat, Thatawan and Tantiworawit, Adisak and Chaiwarith, Romanee and Jariyapan, Narissara and Wannasan, Anchalee and Siriyasatien, Padet and Supparatpinyo, Khuanchai and Bates, Michelle D. and Kwakye-Nuako, Godwin and Bates, Paul A. (2014) First isolation of Leishmania from Northern Thailand:case report, identification as Leishmania martiniquensis and phylogenetic position within the Leishmania enriettii complex. PLoS Neglected Tropical Diseases, 8 (12).

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Abstract

Since 1996, there have been several case reports of autochthonous visceral leishmaniasis in Thailand. Here we report a case in a 52-year-old Thai male from northern Thailand, who presented with subacute fever, huge splenomegaly and pancytopenia. Bone marrow aspiration revealed numerous amastigotes within macrophages. Isolation of Leishmania LSCM1 into culture and DNA sequence analysis (ribosomal RNA ITS-1 and large subunit of RNA polymerase II) revealed the parasites to be members of the Leishmania enriettii complex, and apparently identical to L. martiniquensis previously reported from the Caribbean island of Martinique. This is the first report of visceral leishmaniasis caused by L. martiniquensis from the region. Moreover, the majority of parasites previously identified as "L. siamensis" also appear to be L. martiniquensis.

Item Type:
Journal Article
Journal or Publication Title:
PLoS Neglected Tropical Diseases
Additional Information:
© 2014 Pothirat et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3000
Subjects:
ID Code:
72064
Deposited By:
Deposited On:
08 Dec 2014 09:51
Refereed?:
Yes
Published?:
Published
Last Modified:
05 Jul 2020 04:16