Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest:the randomized CIRC trial

Wik, Lars and Olsen, Jan-Aage and Persse, David and Sterz, Fritz and Lozano Jr, Michael and Brouwer, Marc A. and Westfall, Mark and Souders, Chris and Malzer, Reinhard and Grunsven, Pierre M. van and Travis, David and Whitehead, Anne and Herken, Ulrich R. and Lerner, E. Brooke (2014) Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest:the randomized CIRC trial. Resuscitation, 85 (6). pp. 741-748. ISSN 1873-1570

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Abstract

Objective: To compare integrated automated load distributing band CPR (iA-CPR) with high-quality manual CPR (M-CPR) to determine equivalence, superiority, or inferiority in survival to hospital discharge. Methods: Between March 5, 2009 and January 11, 2011 a randomized, unblinded, controlled group sequential trial of adult out-of-hospital cardiac arrests of presumed cardiac origin was conducted at three US and two European sites. After EMS providers initiated manual compressions patients were randomized to receive either iA-CPR or M-CPR. Patient follow-up was until all patients were discharged alive or died. The primary outcome, survival to hospital discharge, was analyzed adjusting for covariates, (age, witnessed arrest, initial cardiac rhythm, enrollment site) and interim analyses. CPR quality and protocol adherence were monitored (CPR fraction) electronically throughout the trial. Results: Of 4753 randomized patients, 522 (11.0%) met post enrollment exclusion criteria. Therefore, 2099 (49.6%) received iA-CPR and 2132 (50.4%) M-CPR. Sustained ROSC (emergency department admittance), 24 h survival and hospital discharge (unknown for 12 cases) for iA-CPR compared to M-CPR were 600 (28.6%) vs. 689 (32.3%), 456 (21.8%) vs. 532 (25.0%), 196 (9.4%) vs. 233 (11.0%) patients, respectively. The adjusted odds ratio of survival to hospital discharge for iA-CPR compared to M-CPR, was 1.06 (95% CI 0.83–1.37), meeting the criteria for equivalence. The 20 min CPR fraction was 80.4% for iA-CPR and 80.2% for M-CPR. Conclusion: Compared to high-quality M-CPR, iA-CPR resulted in statistically equivalent survival to hospital discharge.

Item Type:
Journal Article
Journal or Publication Title:
Resuscitation
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2705
Subjects:
ID Code:
72034
Deposited By:
Deposited On:
04 Dec 2014 09:52
Refereed?:
Yes
Published?:
Published
Last Modified:
03 Nov 2020 03:25