On selectivity and gating of ionic channels

Luchinsky, D. G. and Tindjong, R. and McClintock, P. V. E. and Kaufman, I. and Eisenberg, R. S. (2007) On selectivity and gating of ionic channels. In: Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems :. PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) . SPIE, ITA. ISBN 9780819467393

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A novel conceptual model is introduced in which ion permeation is coupled to the protein wall vibration and the later in turn modulates exponentially strongly the permeation via radial oscillations of the potential of mean force. In the framework of this model of ion-wall-water interaction we discuss problems of selectivity between alike ions and coupling of ion permeation to gating.

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D. G. Luchinsky; R. Tindjong; P. V. E. McClintock; I. Kaufman; R. S. Eisenberg, "On selectivity and gating of ionic channels" Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems, Proceedings of the Society of Photo-Optical Instruentation Engineers (SPIE), Vol. 6602, 66020D, 2007. Copyright 2007 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/12.724703
?? ion channelsselectivitygatingprotein vibrationbrownian dynamics simulationsmonte-carlo simulationspotassium channelsmolecular-basispermeationgramicidinchargetransitioncontinuummodel ??
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20 Nov 2014 09:27
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02 Mar 2024 00:49