Luchinsky, Dmitrii G. and Tindjong, Rodrigue and Kaufman, Igor and McClintock, Peter V. E. and Khovanov, Igor A. and Eisenberg, Bob S. (2014) Observation of "remote knock-on", a new permeation-enhancement mechanism in ion channels. Biophysical Journal, 106 (2 Supp). 133A. ISSN 0006-3495
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Abstract
We report observation of a novel ‘‘remote knock-on’’ mechanism for enhancement of permeation in Brownian dynamics simulations of a simple model ion channel. Unlike conventional knock-on, which requires a second ion of the same species to enter the channel in order to knock forward and replace an ion already in the channel, the new mechanism does not require the instigating ion to enter the channel, nor that it be of the same species.