Observation of "remote knock-on", a new permeation-enhancement mechanism in ion channels

Luchinsky, Dmitrii G. and Tindjong, Rodrigue and Kaufman, Igor and McClintock, Peter V. E. and Khovanov, Igor A. and Eisenberg, Bob S. (2014) Observation of "remote knock-on", a new permeation-enhancement mechanism in ion channels. Biophysical Journal, 106 (2 Supp). 133A. ISSN 0006-3495

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Abstract

We report observation of a novel ‘‘remote knock-on’’ mechanism for enhancement of permeation in Brownian dynamics simulations of a simple model ion channel. Unlike conventional knock-on, which requires a second ion of the same species to enter the channel in order to knock forward and replace an ion already in the channel, the new mechanism does not require the instigating ion to enter the channel, nor that it be of the same species.

Item Type:
Journal Article
Journal or Publication Title:
Biophysical Journal
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1304
Subjects:
ID Code:
71235
Deposited By:
Deposited On:
14 Oct 2014 07:55
Refereed?:
Yes
Published?:
Published
Last Modified:
08 Jul 2020 04:21