The translational medicine ontology and knowledge base : driving personalized medicine by bridging the gap between bench and bedside

Luciano, Joanne S. and Andersson, Bosse and Batchelor, Colin and Bodenreider, Olivier and Clark, Tim and Denney, Christine K. and Domarew, Christopher and Gambet, Thomas and Harland, Lee and Jentzsch, Anja and Zhao, Jun (2011) The translational medicine ontology and knowledge base : driving personalized medicine by bridging the gap between bench and bedside. Journal of Biomedical Semantics, 2 (Suppl ): S1. ISSN 2041-1480

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Background Translational medicine requires the integration of knowledge using heterogeneous data from health care to the life sciences. Here, we describe a collaborative effort to produce a prototype Translational Medicine Knowledge Base (TMKB) capable of answering questions relating to clinical practice and pharmaceutical drug discovery. Results We developed the Translational Medicine Ontology (TMO) as a unifying ontology to integrate chemical, genomic and proteomic data with disease, treatment, and electronic health records. We demonstrate the use of Semantic Web technologies in the integration of patient and biomedical data, and reveal how such a knowledge base can aid physicians in providing tailored patient care and facilitate the recruitment of patients into active clinical trials. Thus, patients, physicians and researchers may explore the knowledge base to better understand therapeutic options, efficacy, and mechanisms of action. Conclusions This work takes an important step in using Semantic Web technologies to facilitate integration of relevant, distributed, external sources and progress towards a computational platform to support personalized medicine.

Item Type:
Journal Article
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Journal of Biomedical Semantics
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© 2011 Luciano et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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?? health informaticsinformation systemscomputer science applicationscomputer networks and communications ??
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21 Aug 2014 13:28
Last Modified:
04 Apr 2024 23:41