Single amino acid chelate complexes of the M (CO)(3)(+) core for correlating fluorescence and radioimaging studies (M=Tc-99m or Re)

Coogan, Michael and Doyle, Robert P. and Valliant, John F. and Babich, John W. and Zubieta, Jon (2014) Single amino acid chelate complexes of the M (CO)(3)(+) core for correlating fluorescence and radioimaging studies (M=Tc-99m or Re). Journal of Labelled Compounds and Radiopharmaceuticals, 57 (4). pp. 255-261. ISSN 0362-4803

Abstract

Single amino acid chelates (SAACs) and SAAC-like bifunctional ligands can be exploited in the design of a variety of bioconjugates for facile metallation with the M(CO)3+ unit with M = 99mTc or Re. When the donor groups of the ligand are quinolone, thiazole or other similarly conjugated heterocycles, the rhenium complexes are fluorescent, affording complementary and isostructural fluorescent probes to the radioactive 99mTc analogues. The versatility of the approach has been demonstrated by the preparation of bioconjugates incorporating peptides, biotin, folic acid, thymidine and vitamin B12. In addition, the unusual photophysical properties observed for rhenium of the [bisthiazole-diamino butane-Re(CO)3+] derivative [BTBA-Re(CO)3]+ are discussed.